| 发明名称 |
VACCINE |
| 摘要 |
The present invention relates, in general, to an HIV-1 vaccine and, in particular, to a B cell lineage-based vaccination protocol. |
| 申请公布号 |
US2014341949(A1) |
申请公布日期 |
2014.11.20 |
| 申请号 |
US201214349539 |
申请日期 |
2012.10.03 |
| 申请人 |
Children's Medical Center Corporation ;DUKE UNIVERSITY |
发明人 |
Haynes Barton F.;Kelsoe Garnett;Harrison Stephen;Kepler Thomas B. |
| 分类号 |
A61K39/21;G06F19/12;C12N7/00 |
主分类号 |
A61K39/21 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A B cell lineage-based vaccination protocol comprising:
i) identifying a set of clonally related memory B cells, using single cell technology to obtain the native variable heavy (VH) and variable light (VL) chain pairs, ii) inferring with computational methods the unmutated ancestral B-cell receptor, with likely intermediate antibodies (IAs) at each clonal lineage branch point, and iii) designing immunogens with enhanced affinity for UA and IAs, using the UA and IAs as structural templates. |
| 地址 |
Boston MA US |
