3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL][1,4]NAPHTHAQUINONE-ATOVAQUONE PRODRUG

摘要

The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

主权项

1. A compound of formula (I), 1. s2. A process for preparing a compound of formula I comprising:reacting 2-(trans-4-(4-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthalenedione (Atovaquone) of formula (II)with 5-methyl-4-chloromethyldioxalone of formula (III)in the presence of a solvent, to form the compound of formula (I).