| 发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450 2D6 |
| 摘要 |
Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450 2D6. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 2D6 enzymes. |
| 申请公布号 |
US2014343078(A1) |
申请公布日期 |
2014.11.20 |
| 申请号 |
US201414446303 |
申请日期 |
2014.07.29 |
| 申请人 |
Sequoia Pharmaceuticals, Inc. |
发明人 |
EISSENSTAT Michael;DUAN Dehui;KANG Ji-Hye |
| 分类号 |
C07D307/79;A61K31/485;C07D405/12;A61K31/443;A61K31/497;A61K31/444;A61K31/4178;A61K31/4196;C07D471/04;A61K31/437;A61K31/343;C07D405/14 |
主分类号 |
C07D307/79 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound represented by the formula:wherein:J comprises a basic amino group and 1 to 8 carbon atoms optionally containing from 1 to 3 heteroatoms independently selected from the group consisting of O, S, and N;or a salt form thereof; andwherein said compound inhibits cytochrome P450 2D6 enzyme. |
| 地址 |
Potomac MD US |
