PROTEINS COMPRISING MRSA PBP2A AND FRAGMENTS THEREOF, NUCLEIC ACIDS ENCODING THE SAME, AND COMPOSITIONS AND THEIR USE TO PREVENT AND TREAT MRSA INFECTIONS

摘要

Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are disclosed. Novel proteins which comprise a MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed are disclosed. Methods of inducing an immune response against MRSA PBP2a are disclosed, as are methods of treating an individual who has been diagnosed with MRSA and methods of preventing MRSA infection in an individual.

主权项

1. A nucleic acid molecule that encodes an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid, the nucleic acid molecule comprising:
a nucleic acid sequence that is at least 98% homologous to SEQ ID NO:1 and that encodes a protein at least 98% homologous to SEQ ID NO:2; or a fragment of a nucleic acid sequence that is at least 98% homologous to SEQ ID NO:1 and that encodes a protein at least 98% homologous to SEQ ID NO:2, wherein the fragment encodes an immunogenic fragment of a protein that is 98% homologous to a fragment of SEQ ID NO:2 comprises at least 245 amino acids.