发明名称 |
METHOD FOR OBTAINING EPIGENETIC CELL INFORMATION, METHOD FOR DETERMINING CELL CHARACTERISTICS, METHOD FOR ASSESSING DRUG SENSITIVITY OR SELECTING DRUG OR IMMUNOTHERAPEUTIC AGENT VARIETY, DISEASE DIAGNOSIS METHOD, SELF-REPLICATING VECTOR, ASSAY KIT, AND ANALYSIS DEVICE |
摘要 |
An embodiment provides a method for obtaining epigenetic cell information. Said method includes: introducing a reporter nucleic acid structure into the nucleus of a test cell; self-replicating the reporter nucleic acid structure; detecting the presence or absence and/or the magnitude of the signal generated in the test cell; and obtaining epigenetic information on the test cell on the basis of the results obtained. The method is characterized in that the reporter nucleic acid structure copies modifications in a specified sequence on the test cell genome on a corresponding sequence thereof by substitution of functional groups during self-replication inside the nucleus of the test cell and generates a signal that can be detected depending on the circumstances in which the copied functional group is present. |
申请公布号 |
WO2014185549(A1) |
申请公布日期 |
2014.11.20 |
申请号 |
WO2014JP63214 |
申请日期 |
2014.05.19 |
申请人 |
KABUSHIKI KAISHA TOSHIBA;TOSHIBA MEDICAL SYSTEMS CORPORATION |
发明人 |
YOSHIMURA, SEIKO;ISHIHARA, MITSUKO;AKAHOSHI, EIICHI;SAKURAI, YASUO |
分类号 |
C12Q1/68;C12M1/00;C12N15/09 |
主分类号 |
C12Q1/68 |
代理机构 |
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