Hydride transfer process for ketone preparation

摘要

A hydride transfer process within a reaction between an alcohol and a ketone and in the presence of a heterogeneous catalyst is described. The process can transfer a hydride from an alcohol to a ketone, thus enabling reduction of the ketone and oxidation of the alcohol. Further described, is a process for the simultaneous preparation of cyclohexanone and isopropanol enabling an optimized industrial operation. A mixture of compounds useful for implementing the process and comprising two different ketones and two different alcohols is also described.

主权项

1. A process for preparing a ketone of formula (I) and an alcohol of formula (II): the process comprising transferring a hydride, in the presence of a heterogeneous catalyst, between an alcohol of formula (III) and a ketone of formula (IV), present in a (III)/(IV), alcohol of formula (III)/ketone of formula (IV), molar ratio ranging from 1/8 to 1/2, said catalyst being selected from the group consisting of a zeolite, a hydroxyapatite with a Ca/P atomic ratio, a tricalcium phosphate, a magnesium phosphate, an olivine, an alumina and a rare-earth oxide, alone or as a mixture with other oxides, in which: n represents an integer ranging from 1 to 9; and R1 and R2 independently represent a C1-C10 hydrocarbon-based group.