NOTCH inhibition in the treatment and prevention of a metabolic disease or disorder and cardiovascular complications thereof

摘要

The present invention is directed to methods of treating or preventing a metabolic disease or disorder and cardiovascular complications and other complications thereof by administering agents that inhibit the NOTCH signaling pathway. In addition, the invention encompasses methods for determining whether a patient is at increased risk for developing these conditions by determining the amount, function, or activity of NOTCH pathway components in biological samples derived from the patient or in imaging analysis.

主权项

1. A method of treating a patient for metabolic syndrome comprising administering to said patient a therapeutically effective amount of an antibody that binds to Delta-like 4 (DLL4) and inhibits the NOTCH signaling pathway.