发明名称 |
Dendrimer conjugates |
摘要 |
The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. |
申请公布号 |
US8889635(B2) |
申请公布日期 |
2014.11.18 |
申请号 |
US200912570977 |
申请日期 |
2009.09.30 |
申请人 |
The Regents of The University of Michigan |
发明人 |
Baker, Jr. James R.;Cheng Xue-min;Van Der Spek Abraham F. L.;Huang Baohua Mark;Thomas Thommey P. |
分类号 |
A61K31/5513;A61K31/485;A61K31/5377;C07D489/02;A61K47/48 |
主分类号 |
A61K31/5513 |
代理机构 |
Casimir Jones SC |
代理人 |
Casimir Jones SC |
主权项 |
1. A composition comprising pain relief complexes and pain relief antagonist complexes;
wherein said pain relief complexes consist of dendrimers separately conjugated with 1) a pain relief agent via an ester linkage agent, wherein said pain relief agent is morphine, 2) a locking agent, wherein said locking agent is trigonelline, and 3) a targeting agent, wherein said targeting agent is transferrin; wherein said pain relief antagonist complexes consist of dendrimers separately conjugated with 1) a pain relief agent antagonist via an indolequinone trigger agent, wherein said pain relief agent antagonist is naloxone, 2) a locking agent, wherein said locking agent is trigonelline, and 3) a targeting agent, wherein said targeting agent is transferrin; wherein said pain relief antagonist complexes are configured to prevent respiratory depression caused said pain relief complexes; wherein said dendrimers within said pain relief complexes and pain relief antagonist complexes are separate within said composition. |
地址 |
Ann Arbor MI US |