IAP antagonists

摘要

There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

主权项

1. A compound of Formula (I)wherein
X is a direct bond, —NH—, —O—, —NHCO— or —CONH—; R1 is optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl; R2 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted thioalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted arylalkyl or optionally substituted aryl; R3 and R4 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl or optionally substituted heterocycloalkyl; R5 and R6 are independently hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; R7 and R8 are independently hydrogen or optionally substituted alkyl; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.