发明名称 |
Methods for treating obesity or an obesity related condition |
摘要 |
In one aspect of the present invention, a pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of (R)-all-trans-13,14-dihydroretinol and a pharmaceutically acceptable carrier or diluent. In another aspect of the present invention, pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of (S)-all-trans-13,14-dihydroretinol and a pharmaceutically acceptable carrier or diluent. In a further aspect of the present invention, a method is provided for treating a metabolic disease in a mammalian subject. The method includes administering to the subject a pharmaceutical composition comprising at least one all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid derivative, or agent capable of modulating the level of at least one all-trans-13,14-dihydroretinoid or all-trans-13,14-dihydroretinoid derivative in the subject. |
申请公布号 |
US8889660(B2) |
申请公布日期 |
2014.11.18 |
申请号 |
US201213679592 |
申请日期 |
2012.11.16 |
申请人 |
Case Western Reserve University |
发明人 |
Palczewski Krzysztof;Moise Radu |
分类号 |
A61K31/59;A61K31/203;A61K31/07;A61K31/215 |
主分类号 |
A61K31/59 |
代理机构 |
Tarolli, Sundheim, Covell & Tummino LLP |
代理人 |
Tarolli, Sundheim, Covell & Tummino LLP |
主权项 |
1. A method of treating obesity or an obesity related condition in a mammalian subject, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising at least one all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid derivative, or all-trans-retinol: all-trans-13,14-dihydroretinol saturase, wherein the obesity or obesity related condition is associated with improved glucose tolerance, abnormal fasting response manifested by visceral fat retention, or decreased hepatic triglyceride levels. |
地址 |
Cleveland OH US |