Compositions and methods for modulating PGC-1β to treat lipid-related diseases and disorders

摘要

The present invention provides methods for treating lipid-related diseases and disorders, e.g., hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, cardiovascular disease, obesity, and type II diabetes, and for modulating lipid biosynthesis, lipid transport, plasma triglyceride levels and/or plasma cholesterol levels, by modulating the expression or activity of PGC-1β. Methods for identifying compounds which are capable of treating or preventing a lipid-related disease or disorder are also described.

主权项

1. A method for treating a lipid-related disease or disorder in a subject in need thereof comprising the step of administering to the subject a peroxisome proliferator-activated receptor gamma coactivator 1β (PGC-1β) modulator, wherein the PGC-1β modulator specifically modulates PGC-1β expression or activity, such that the lipid-related disease or disorder is treated, and wherein the PGC-1β modulator is a nucleic acid.