| 发明名称 | Methods of inhibiting seizure in a subject | ||
| 摘要 | The present invention relates to methods of inhibiting seizure in a subject. In particular, the invention provides methods of increasing brain leptin levels in a subject. | ||
| 申请公布号 | US8889622(B2) | 申请公布日期 | 2014.11.18 |
| 申请号 | US200812179856 | 申请日期 | 2008.07.25 |
| 申请人 | Washington University | 发明人 | Thio Kwee Liu Lin;Yamada Kelvin A. |
| 分类号 | A61P3/04;A61K38/26;G01N33/48;A61K38/22;A61K31/00 | 主分类号 | A61P3/04 |
| 代理机构 | Polsinelli PC | 代理人 | Polsinelli PC |
| 主权项 | 1. A method of inhibiting seizures in a subject in need thereof, the method comprising intranasally administering a composition comprising leptin to the subject in need of treatment for seizures, wherein leptin is the mature protein product of the obese (ob) gene of the subject, such that brain leptin levels in the subject are increased to greater than 15 pg/mg of total brain protein, and seizures in the subject are inhibited. | ||
| 地址 | St. Louis MO US | ||