| 发明名称 | Recombinant codon optimised factor H | ||
| 摘要 | The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials. | ||
| 申请公布号 | US8889374(B2) | 申请公布日期 | 2014.11.18 |
| 申请号 | US201013518614 | 申请日期 | 2010.12.23 |
| 申请人 | University Court of the University of Edinburgh | 发明人 | Schmidt Christoph;Barlow Paul N.;Richards Anna |
| 分类号 | C12P21/06;C07H21/02;C07H21/04;C12P1/02;C12P1/04;C12P21/04;C12N1/00;C12N5/04;C12N5/10;C12N5/00;C12N5/02;C12N15/00;A61K38/16;C07K1/16;C07K14/00;C07K14/435;C07K14/47 | 主分类号 | C12P21/06 |
| 代理机构 | Barnes & Thornburg LLP | 代理人 | Barnes & Thornburg LLP |
| 主权项 | 1. A method for making a recombinant mammalian factor H (FH), the method comprising the step of: expressing in a bacterial, fungal, insect or plant cell, in culture a codon-optimized nucleic acid sequence encoding the mammalian FH, the nucleic acid sequence comprising a deletion variant sequence of any one of SEQ ID NO: 1-13 thereof comprising domains 1-4 and 19-20 and a deletion of domains 8-18, wherein the nucleic acid sequence has been codon optimized to enhance expression in the bacterial, fungal, insect or plant cell and inserted into an expression vector. | ||
| 地址 | Edinburgh GB | ||