Substituted triazoles useful as mGlu5 receptor modulators

摘要

This invention relates to compounds of formula I;
their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

主权项

1. A compound of formula I in which A and B independently represent CH or N; R1 represents phenylethynyl, C3-6cycloalkylethynyl, C2-5alkenyl, C5-7cycloalkenyl, aryl, heteroaryl, C1-8alkyl, C3-7cycloalkyl or —O—C1-8alkyl which latter five groups are optionally substituted with one or more substituents selected from halogen, cyano, C1-3alkyl, C3-6cycloalkyl, —O—C1-3alkyl, —CH2—O—CH3, —CH2-morpholine and —CH2CN which latter six substituents are optionally substituted with one or more fluorine atoms; R2 and R3 independently represent —H, halogen,—CN, —COO—C1-4alkyl, C1-5alkyl, C3-5cycloalkyl or —O—C1-5alkyl which latter four groups are optionally substituted with one or more fluorine atoms; Ar represents; or a physiologically acceptable salt thereof.