| 发明名称 | C-terminal fragments of glucagon-like peptide-1 (GLP-1) | ||
| 摘要 | C-Terminal Fragments of Glucagon-Like Peptide-1 (GLP 1), and methods of use thereof, e.g., for the treatment of obesity and obesity-related disorders, e.g., diabetes and the metabolic syndrome. | ||
| 申请公布号 | US8889618(B2) | 申请公布日期 | 2014.11.18 |
| 申请号 | US200913127387 | 申请日期 | 2009.11.09 |
| 申请人 | The General Hospital Corporation | 发明人 | Habener Joel F.;Yano Tatsuya;Falco Eva Tomas |
| 分类号 | A61K9/127;A61K38/26;A61P7/12;C07K14/605;A61K38/00;A61P3/10;C07K2/00;C07K4/00;C07K5/00;C07K7/00;C07K14/00;C07K16/00;C07K17/00;A61K38/04 | 主分类号 | A61K9/127 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. An isolated peptide consisting of the amino acid sequence: (Phe/Tyr)-Ile-Ala-Trp-Leu-Val-(Lys/Arg)-Gly-Arg-Xaa (SEQ ID NO:1), wherein Xaa can be Gly-Arg, or Gly-Arg-Gly, or absent, wherein one or more amino acids of the isolated peptide are modified by attachment of a fatty acid, or are alkylated, acylated, or biotinylated. | ||
| 地址 | Boston MA US | ||