High shear application in medical therapy

摘要

In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

主权项

1. A method comprising:
mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion, wherein said high shear device comprises at least one rotor and at least one complementarily-shaped stator; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains bubbles of said therapeutic gas or droplets of said therapeutic liquid, wherein said bubbles of said therapeutic gas or said droplets of said therapeutic liquid have a mean diameter of less than 1 nanometer.