Fibrous calcium pyrophosphate particles and methods of making and using same

摘要

Fibrous calcium pyrophosphate particles with a unique fibrous nanostructure are disclosed. The invention includes a composition, comprising fibrous particles, wherein the fibrous particles include fibers and the fibers include calcium and pyrophosphate. Also included are methods for making calcium pyrophosphate particles wherein solutions of calcium salt and pyrophosphate salt are combined to form the particles. Pharmaceutical compositions and methods for treating a patent using the disclosed particles are also described.

主权项

1. Isolated, spherical, porous, amorphous calcium pyrophosphate particles having a diameter between 15 μm and 100 μm, and an unloaded relative porosity of 30% to 90%.