发明名称 |
Treatment or prevention of fungal infections with PDK1 inhibitors |
摘要 |
Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise identifying a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of an inhibitor or a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof. Inhibition of the fungal PDK-1 or homolog thereof results in the treatment or prevention of a fungal infection in the subject. Also provided are compositions comprising an inhibitor of a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof, and a pharmaceutically acceptable carrier. |
申请公布号 |
US8889680(B2) |
申请公布日期 |
2014.11.18 |
申请号 |
US201113298766 |
申请日期 |
2011.11.17 |
申请人 |
University of Rochester |
发明人 |
Krysan Damian;DiDone Louis;Baxter Bonnie K. |
分类号 |
A01N43/64;A01N37/18;A61K38/00;A61P31/10 |
主分类号 |
A01N43/64 |
代理机构 |
Kilpatrick Townsend & Stockton, LLP |
代理人 |
Kilpatrick Townsend & Stockton, LLP |
主权项 |
1. A method of treating a fungal infection in a subject, the method comprising:
(a) identifying a subject with a fungal infection, and (b) administering to the subject a therapeutically effective amount of OSU-03012 and a therapeutically effective amount of fluconazole, wherein the fungal infection is caused by Cryptococcus neoformans. |
地址 |
Rochester NY US |