发明名称 |
Composicion que comprende anticuerpo biespecífico cd19xcd3 para tratar masa tumoral de tejido de ganglios linfáticos y/o linfoma extranodal causado por el linfoma b difuso de células grandes (lbdcg); kit farmacéutico; uso de la composición. |
摘要 |
The present invention provides means and methods for treating diffuse large B cell lymphoma (DLBCL). Specifically, a bispecific CD19 x CD3 antibody which engages T cells via its CD3 binding portion and concomitantly binds to CD19 on the surface of, in particular, lymphoma cells via its CD19 binding portion (i.e. a bispecific T cell engager, "BiTE") is administered for use in the treatment of tumorous mass of lymophoreticular tissue and/or extranodal lymphoma caused by DLBCL in a patient. |
申请公布号 |
CL2013001138(A1) |
申请公布日期 |
2014.11.14 |
申请号 |
CL20130001138 |
申请日期 |
2013.04.25 |
申请人 |
AMGEN RESEARCH (MUNICH) GMBH |
发明人 |
ZUGMAIER GERHALD;NAGORSEN, DIRK;SCHEELE, JUERGEN |
分类号 |
A61K39/395;A61P35/00;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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