METHODS OF IDENTIFYING MODULATORS OF OSBPL7 AND THE USE OF SUCH MODULATORS FOR TREATMENT OF DISEASES ASSOCIATED WITH OSBPL7
摘要
<p>The present invention refers to an assay method for determining the ability of compounds to modulate the function and distribution of OSBPL7 protein in cells and its use in drug discovery and screening. The invention also refers to the use of pyridine carboxamides as OSBPL7 modulators that are useful for the treatment of diseases such as diabetes.</p>
申请公布号
WO2014180741(A1)
申请公布日期
2014.11.13
申请号
WO2014EP58961
申请日期
2014.05.02
申请人
F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC.
发明人
BEAUCHAMP, JEREMY;HARTUNG, THOMAS;KEMMER, CHRISTIAN;MOHR, PETER;ROEVER, STEPHAN;WRIGHT, MATTHEW