MALE TESTOSTERONE TITRATION METHODS, INTRANASAL TESTOSTERONE BIO-ADHESIVE GEL FORMULATIONS AND TREATMENT OF HYPOGONADISM AND TRT

摘要

The present invention relates to pernasal testosterone bio-adhesive gel formulations for intranasal administration and testosterone replacement treatment methods for using the pernasal testosterone bio-adhesive gel formulations for providing sustained intranasal delivery of testosterone to testosterone deficient males to treat, for example, male subjects diagnosed with hypogonadism. The present invention is also concerned with a novel titration method to determine the appropriate daily treatment regimen, i.e., a BID or TID treatment regimen, to administer the intranasal gels of the present invention to treat hypogonadism or TRT.