| 摘要 |
The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents. |
| 主权项 |
1. A complexing agent of formula (I): in which: either a=b=c=1, or a=b=c=0, or a=1 and b=c=0, or a=b=1 and c=0; R3, R4 and R5 are each independently H or a group -L-G; Chrom1, Chrom2 and Chrom3 are identical or different chromophores and all three correspond to only one of the following formulae: in which
d is an integer ranging from 1 to 3;each R1 is a group —COOH or —PO(OH)R6, R6 representing a group phenyl, benzyl, methyl, ethyl, propyl, n-butyl, sec-butyl, isobutyl, or tert-butyl;R21 and R22 represent, independently of each other, a hydrogen atom or a linear or branched alkyl comprising from 1 to 6 carbon atoms;each R2 is:
a linear or branched alkyl groups comprising from 1 to 6 carbon atoms optionally substituted with a PEG group;an O-donating group selected from: OH; —OPhenyl; —O—CH2—CO—N-Alk; —O—CH2—CO—O-Alk; —O—CH2—CO—NH; —O—CH2—CO—OH; O—CH2—CO—N-LG; —O—CH2—CO—O-L-G; —O-L-G; —O-Alk; —O-PEG; the group of formula: in which z is an integer ranging from 1 to 5;a S-donating group selected from: —S-L-G; —S-Alk; —S-PEG; the group of formula: in which z is an integer ranging from 1 to 5;a NHCO-donating group selected from: —NHCO-L-G; —NHCO(OAlk); —NHCO(NHAlk); —NHCO(NAlk1Alk2); —NHCO(SAlk); —NHCO(Alk); —NHCO-PEG; —NHCO-phenyl; a group of formula: a SCO-donating group selected from: —SCO-L-G; —SCO(OAlk); —SCO(NHAlk); —SCO(NAlk1Alk2); —SCO(SAlk); —SCO(Alk); —SCO-PEG;a NHCS-donating group selected from: —NHCS(OAlk); —NHCS(NHAlk); —NHCS(NAlk1Alk2); —NHCS(SAlk); —NHCS(Alk); —NHCS-PEG; —NHCS-L-G; ora SCS-donating group selected from: —SCS(OAlk); —SCS(NHAlk); —SCS(NAlk1Alk2); —SCS(SAlk); —SCS(Alk); —SCS-PEG; —SCS-L-G;PEG is a group of formula —CH2—(CH2OCH2)y-CH2OCH3, y being an integer ranging from 1 to 5;Alk, Alk1 and Alk2 are each a linear or branched C1-C10 alkyl optionally substituted with an —O-PEG group;
L is a spacer arm;G is a reactive group for linking the complex or the complexing agent to a molecule to be labeled; it being understood that: when R22 and R21 are alkyl groups, then d=1 and when one of the groups R22 or R21 is an alkyl group and the other is a hydrogen atom, then d=1 or d=2; when R2 comprises a group -L-G, then R3═R4═R5═H; when R2 does not comprise a group -L-G, then either one of the groups R3, R4 and R5 is a group -L-G or R3═R4═R5═H; and when several groups R2 are present, at least one is in position 4 of the benzene ring. |
