发明名称 |
Biodegradable Nanoparticles as Novel Hemoglobin-Based Oxygen Carriers and Methods of Using the Same |
摘要 |
Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers that encapsulate an oxygen-binding compound in a polymer vesicle. Oxygen-binding compounds may include hemoglobin, myoglobin, or other oxygen binding compounds having characteristics similar to hemoglobin. Oxygen carriers may include nanoparticles, polymers and/or polymersomes comprising of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) and related diblock copolymers of poly(ethylene oxide)-block-poly(γ-methyl ε-caprolactone) (PEO-b-PMCL). The oxygen carriers may have tunable oxygen-binding capacities, uniform and appropriately small size distributions, and human bloodlike viscosities and oncotic properties. |
申请公布号 |
US2014335159(A1) |
申请公布日期 |
2014.11.13 |
申请号 |
US201414339714 |
申请日期 |
2014.07.24 |
申请人 |
Vindico NanoBio Technology Inc. |
发明人 |
Ghoroghchian P. Peter;Ostertag Eric |
分类号 |
A61K38/42;A61K47/32;A61K9/10;A61K9/127;A61K45/06 |
主分类号 |
A61K38/42 |
代理机构 |
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代理人 |
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主权项 |
1. A composition, comprising:
an oxygen carrier comprising:
a plurality of polymers; andan oxygen-binding compound, wherein oxygen is dispersed within the plurality of polymers of the oxygen carrier. |
地址 |
Lexington KY US |