LOW-OIL PHARMACEUTICAL EMULSION COMPOSITIONS COMPRISING PROGESTOGEN

摘要

Described are sterile, ready-to-use, pharmaceutical oil-in-water emulsion compositions for parenteral administration comprising:
0.015 to 0.5% wt/vol progesterone;0.5 to 10% wt/vol oil, wherein the oil comprises at least 85% wt./wt. triglyceride;0.0425 to 4.1% wt/vol phospholipid;80-99.4% wt/vol aqueous medium;

wherein the composition has an osmolality in the range of 200-1000 mOsm/kg.
;Also described are methods of making such compositions and method of using such compositions in therapeutic or prophylactic treatment, such as treatments comprising intravenous administration of the pharmaceutical composition.