发明名称 |
BINDING DRUGS WITH NANOCRYSTALLINE CELLULOSE (NCC) |
摘要 |
This invention describes nanocrystalline cellulose (NCC) for use as a drug delivery excipient. NCC binds significant quantities of water soluble, ionizable drugs, e.g., tetratcycline and doxorubicin, which are released rapidly over a one day period. A surfactant such as cetyl trimethylammonium bromide (CTAB) can bind to the surface of NCC and increase the zeta potential in a concentration-dependent manner from −55 to 0 mV. NCC with CTAB modified surfaces can bind significant quantities of the hydrophobic drugs such as anticancer drugs docetaxel, paclitaxel and etoposide. These drugs were released in a controlled manner over a 2-day period. The NCC-CTAB nanocomplexes were found to bind to KU-7 cells and evidence of cellular uptake was observed. |
申请公布号 |
US2014335132(A1) |
申请公布日期 |
2014.11.13 |
申请号 |
US201113885503 |
申请日期 |
2011.11.22 |
申请人 |
Burt Helen Mary;Jackson John Kevin;Hamad Wadood Yasser |
发明人 |
Burt Helen Mary;Jackson John Kevin;Hamad Wadood Yasser |
分类号 |
A61K47/48;A61K31/65;A61K45/06;A61K31/704 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical composition comprising a drug bound to a carrier comprising nanocrystalline cellulose (NCC). |
地址 |
Vancouver CA |