POLYPEPTIDE DERIVED FROM gp41, A VACCINE COMPOSITION COMPRISING SAID POLYPEPTIDE, AND USES FOR TREATING AN INFECTION BY AN HIV VIRUS IN AN INDIVIDUAL

摘要

The present invention relates to the field of the in vitro diagnosis of the progression status of an infection of an individual with a virus belonging to the family of the Human Immunodeficiency Viruses (HIV) as well as with the therapeutical treatment of this infectious disease. The invention also relates to immunological compounds and vaccine compositions comprising a polypeptide derived from gp41.

主权项

1. A method for treating an HIV infected patient, comprising administering to an individual an effective amount of an antigenic polypeptide of the following formula (III):
NH2-PepNt-[(I)n-PepXn]n-PepCt-COOH  (III),wherein:
“PepNt” consists of a polypeptide having an amino acid length from 2 to 10 amino acid residues and located at the N-terminal end of the polypeptide of formula (III); “[(I)n-PepXn]” consists of a polypeptide unit wherein:
“(I)1” to -“(I)n” each consists of, one independently from each other, a polypeptide of formula “SWSNKS”, with n being an integer of 1; and“PepX1” to “PepXn” each consists of, one independently from the other, a spacer polypeptide having an amino acid length of 0 amino acid residues, with n being an integer of from 1 to 12; n is the number of [(I)n-PepXn] polypeptide units in said polypeptide, with n being an integer of from 1 to 12; and “PepCt” consists of a polypeptide having an amino acid length from 2 to 10 amino acid residues and located at the C-terminal end of the polypeptide of formula (III),wherein the said antigenic polypeptide raises an antibody response that does not neutralize the HIV virus and that inhibits the cytotoxicity of NK cells towards CD4+ T cells in patients infected by HIV.