| 主权项 |
1. A method of treating cancer in a patient, comprising the step of administering an effective amount of a compound under Formula 1:or a pharmaceutically acceptable salt thereof, wherein:
R1 is:wherein
E is either present or absent, and when present is selected from the group consisting of H, halo, OH, CN, —O(C1-C6)alkyl, —(C1-C6)alkyl, —C(O)OH, —C(O)NR8R8′, —(C1-C6)alkyl-C(O)OH, —(C1-C6)alkyl-OH, —(C1-C6)alkyl-C(O)NR8R8′, (C2-C6)alkenyl, —(C2-C6)alkynyl, heterocyclyl, and heteroaryl; each J independently is selected from the group consisting of H and halogen; Y and R may or may not be present, when Y is present, it is selected from the group consisting of O, S, NR8, SO2, and CR8R8′; R when present is one or more moieties independently selected from the group consisting of —(C1-C6)alkyl, and —(CR8R8′)n—C(O)OH; G is present and is selected from the group consisting of —(CR8R8′)n—C(O)OH, —(CR8R8′)n—C(O)NR8R9, —(CR8R8′)n—(C3-C8)Cycloalkyl-C(O)NR8R9, —(CR8R8′)n—(C3-C8)cycloalkyl-(CR8R8′)n—C(O)OH, —(CR8R8′)n—O—(CR8R8′)n—(C3-C8)cycloalkyl-(CR8R8′)n—C(O)OH, —(CR8R8′)n—O—(CR8R8′)n—C(O)OH, —(CR8R8′)n—S—(CR8R8′)n—C(O)OH, C(O)OH, —(CR8R8′)n—NH—(CR8R8′)n—C(O)OH, —(CR8R8′)n—O—(CR8R8′)n—CH3, —(CR8R8′)n—S—(CR8R8′)n—CH3, —(CR8R8′)n—NH—(CR8R8′)n—CH3, —(CR8R8′)n—CH3, —(CR8R8′)n-heteroaryl, —(CR8R8′)n—P(O)OR8OR8′, and —(CR8R8′)n—OH; each R8 and R8′ is independently selected from the group consisting of H, D, and (C1-C6)alkyl; or wherein R8 and R8′ together with the carbon to which each is attached form (C3-C8)cycloalkyl; each R9 independently is SO2(C1-C6)alkyl or SO2(C3-C8)cycloalkyl; each n independently is 0-10; provided that when n is 0, any oxygen, nitrogen or sulfur atom of Y is not directly linked to any oxygen, nitrogen, sulfur or phosphorus atom of G; represents a single or a double bond, provided that when E is present, represents a single bond; R2 is R4, R4′, R5, R5′, R6, R6′, R7, and R7′ independently are selected from the group consisting of hydrogen and (C1-C6)alkyl; and X is |
