发明名称 |
STRUCTURE-BASED PEPTIDE INHIBITORS OF P53 AGGREGATION AS A NEW APPROACH TO CANCER THERAPEUTICS |
摘要 |
This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described. |
申请公布号 |
WO2014182961(A1) |
申请公布日期 |
2014.11.13 |
申请号 |
WO2014US37387 |
申请日期 |
2014.05.08 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
EISENBERG, DAVID S.;SORAGNI, ALICE;JIANG, LIN |
分类号 |
C07K7/06;A61K38/08;A61P35/00;C12N15/63 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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