发明名称 |
COMPOSITION COMPRISING ASM INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DEGENERATIVE NEUROLOGICAL DISORDERS |
摘要 |
The present invention relates to a composition comprising an ASM inhibitor as an active ingredient for preventing or treating degenerative neurological diseases. According to the present invention, when ASM is partially removed in an Alzheimer's disease model mouse, that is when ASM is inhibited therein, such when as an Alzheimer's disease model mouse with a partial removal of ASM is in a parabionic union with an Alzheimer's disease model mouse, or when an Alzheimer's disease model mouse is injected with the serum of an Alzheimer's disease model mouse from which ASM gene has been removed, the deposition of &bgr;-amyloid in the brain tissue is inhibited and the ability to learn and remember are improved, and the present invention confirms such superb effects. Accordingly, ASM inhibitor can be effectively used to prevent or treat degenerative neurological diseases. |
申请公布号 |
WO2014182051(A1) |
申请公布日期 |
2014.11.13 |
申请号 |
WO2014KR04025 |
申请日期 |
2014.05.07 |
申请人 |
KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION |
发明人 |
BAE, JAE SUNG;JIN, HEE KYUNG;LEE, JONG KIL |
分类号 |
A61K39/395;A61K48/00;A61P25/16;A61P25/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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