| 摘要 |
<p>The present invention relates to an assay for assessing the production of proinflammatory cytokines in human skin, and for assessing the effect of test compounds on such production. The invention provides a method of screening a compound for the ability to modulate pro-inflammatory cytokine production in human skin, using a liquid-air interface culture of human skin, exposing the skin to a test compound, exposing the skin to a Th17 activating condition, measuring the production of proinflammatory cytokines, and comparing the production of pro-inflammatory cytokines to that produced in the absence of the test compound.</p> |
