Method for synthesizing (E)-Anethol and Related Compounds By Cross Coupling Reaction of Potassium allyltrifluroborate and 4-bromoanisole and aryl halides

摘要

Methods of producing substituted and non-substituted beta-methyl styrene by a cross-coupling reaction are provided. The disclosure also provides for methods of preparing (E)-Anethol and related compounds by a cross coupling reaction of potassium allyltrifluoroborate and 4-bromoanisole and aryl halides. Compounds, compositions, and methods of treating disorders utilizing beta-methyl styrene are also provided.

主权项

1. A method of synthetically producing styrene by a reaction comprising
reacting a potassium trifluoroborate with an aryl halide compound of Formula (I) wherein X is selected from the group consisting of I, Br, OTf, ONf, ODs, and OAc; and Z is selected from the group consisting of F, Cl, Br, I, CN, —SO3H, —CO2H, —CHO, —NO2, CF3, CCl3, and an alkyl group; and wherein said reaction is catalyzed by a palladium salt.