COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES

摘要

The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.

主权项

1. A pharmaceutical composition comprising a compound of Formula II: wherein,
Z is O or S;Y is O, NR25 or CR26R27;each R21 and R22 is, independently, halo, hydroxy, nitro, cyano, amino, amido, or alkyl; R23 is alkyl, cyclyl, aryl, heteroaryl, cyclylalkyl, arylalkyl, or heteroarylalkyl, or when taken together with R24 and the nitrogen to which it is attached forms a ring; wherein R23 is optionally substituted with 1-3 R28.
R24 is H, alkyl, or when taken together with R23 and the nitrogen to which it is attached forms a ring; wherein R24 is optionally substituted with 1-3 R28.R25 is H or alkyl;each R26 and R27 is independently H or alkyl;each R28 is independently halo, hydroxy, nitro, cyano, amino, amido, or alkyl;each p and q are independently an integer from 0-4.