Polymer Blends For Drug Delivery Stent Matrix With Improved Thermal Stability

摘要

Various embodiments of the present invention generally relate to a polymer blend composition used for coating a medical device that exhibits improved thermal stability. The invention also encompasses implantable medical devices coated the aforementioned coating.

主权项

1. An implantable medical device comprising a coating, the coating comprising:
a polymer blend composition, the polymer blend composition comprising:
a semi-crystalline polymer with a weight-average-molecular-weight from about 75,000 daltons to about 300,000 daltons;andan amorphous, or substantially amorphous, polymer with a weight-average-molecular weight from about 75,000 daltons to about 300,000 daltons; wherein
the semi-crystalline polymer is between about 2% and about 75% by weight of the sum of the semi-crystalline and the amorphous, or substantially amorphous, polymer; wherein
the coating comprises about 0.5% to about 50% by weight polymer crystallinity; andthe coating has a dynamic shear storage modulus that is greater than the dynamic shear loss modulus, where both are measured at the temperature of and under the conditions of ethylene oxide sterilization, and measured in the linear viscoelastic range at 1 radian/second, and the dynamic shear loss modulus is about 2×104 Pa or less.