发明名称 |
Buffers for Controlling the pH of Bone Morphogenetic Proteins |
摘要 |
The present invention provides formulations of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins that are pH stabilized. In particular, the present invention relates to the observation that certain buffers enhance the stability of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins. In particular, disclosed herein are liquid and lyophilized formulations prepared with a glycylglycine and tartaric acid buffers to stabilize the pH of the formulation. |
申请公布号 |
US2014336114(A1) |
申请公布日期 |
2014.11.13 |
申请号 |
US201314088623 |
申请日期 |
2013.11.25 |
申请人 |
Hile David D.;Strohmeier Gregg |
发明人 |
Hile David D.;Strohmeier Gregg |
分类号 |
A61K38/18;A61K47/12;A61K47/26;A61K47/18 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Westborough MA US |