| 发明名称 |
COMPOUND AND METHOD FOR THERAPY OF INFLAMMATORY AND FIBROTIC DISEASE |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound and method for therapy of inflammatory and fibrotic diseases.SOLUTION: Disclosed are a compound and method for therapy of inflammatory diseases and fibrotic diseases, including a method of regulating stress-activated protein kinase (SAPK) with an active compound, where the active compound exhibits low efficacy due to inhibition of p38MAPK; contacting is conducted at a SAPK regulate concentration which is a low percentage of inhibition concentration for inhibition of p38MAPK by the compound. Disclosed are also a derivative and analog of pirfenidone useful for regulating a stress-activated protein kinase (SAPK) system. |
| 申请公布号 |
JP2014210809(A) |
申请公布日期 |
2014.11.13 |
| 申请号 |
JP20140161019 |
申请日期 |
2014.08.07 |
| 申请人 |
INTERMUNE INC |
发明人 |
KARL KOSSEN;SCOTT D SEIWERT;VLADIMIR SEREBRYANY;DONALD RUHRMUND;LEONID BEIGELMAN;LUCA FRANCESCO MARIO RAVEGLIA;STEFANIA VALLESE;IVANA BIANCHI;HU TAO |
| 分类号 |
C07D213/64;A61K31/437;A61K31/4412;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61K31/496;A61K31/4965;A61K31/50;A61K31/506;A61K31/513;A61K31/53;A61K31/5377;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P5/16;A61P7/00;A61P7/02;A61P7/04;A61P7/06;A61P9/00;A61P9/04;A61P11/00;A61P11/06;A61P13/02;A61P13/12;A61P17/06;A61P17/08;A61P19/02;A61P19/06;A61P19/08;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/04;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P31/00;A61P31/04;A61P31/16;A61P31/18;A61P31/22;A61P33/02;A61P33/06;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07D213/69;C07D213/70;C07D213/75;C07D213/85;C07D237/14;C07D239/10;C07D239/22;C07D239/36;C07D239/54;C07D241/18;C07D251/16;C07D401/04;C07D401/14;C07D405/04;C07D405/14;C07D409/04;C07D413/04;C07D413/14;C07D417/04;C07D471/04 |
主分类号 |
C07D213/64 |
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