| 发明名称 |
HUMAN CONDUCTING AIRWAY MODEL COMPRISING MULTIPLE FLUIDIC PATHWAYS |
| 摘要 |
A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided. |
| 申请公布号 |
US2014335496(A1) |
申请公布日期 |
2014.11.13 |
| 申请号 |
US201214362419 |
申请日期 |
2012.12.04 |
| 申请人 |
Research Triangle Institute ;The University of North Carolina at Chapel Hill |
发明人 |
Grego Sonia;Gilchrist Kristin Hedgepath;Randell Scott H. |
| 分类号 |
G09B23/30 |
主分类号 |
G09B23/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An airway tissue model system comprising:
a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. |
| 地址 |
Research Triangle Park NC US |
