AMPHIPHILIC RESIN LINEAR COPOLYMERS FOR PHARMACEUTICAL DRUG DELIVERY APPLICATIONS

摘要

The present disclosure relates to a drug delivery formulation. The drug delivery formulation includes an amphiphilic resin-linear copolymer, a resin-linear organosiloxane block copolymer, or a combination thereof in a first solvent, wherein the first solvent is configured to dissolve the amphiphilic resin-linear copolymer or the resin-linear organosiloxane block copolymer; at least one active ingredient configured to be topically delivered through skin for an intended therapeutic application; and at least one penetration enhancer or penetration excipient. The formulation may additionally include a solid silicone resin. The formulation may additionally include an occlusivity agent. The formulation is configured to form a temporary film on the substrate onto which the formulation is applied.