PRODUCTION METHOD OF SUBSTRATE HAVING HYDROPHILIC LAYER

摘要

PROBLEM TO BE SOLVED: To provide a method for stably introducing a high-quality hydrophilic layer capable of sufficiently inhibiting nonspecific adsorption of a bio-related substance such as protein into a plastic surface of a substrate.SOLUTION: A production method of a substrate having a hydrophilic layer on a surface thereof is provided, which includes: a substrate preparation step of preparing a substrate having a plastic surface; a plasma treatment step 1 of exposing the plastic surface of the substrate to plasma containing rare gas; a plasma treatment step 2 of exposing the plastic surface of the substrate to plasma containing fluorocarbon gas; a primer layer formation step of forming a primer layer containing polysiloxane by polymerizing a silanol compound having an organic group that contains a carbon atom directly bonded to a silicon atom and has a functional group, on the surface of the substrate exposed to plasma; and a hydrophilic layer formation step of linking the primer layer with a hydrophilic polymer via a covalent bond by the reaction of the functional group on a side chain of the polysiloxane with a functional group of the hydrophilic polymer.