主权项 |
1. A topical patch comprising a therapeutic compound-impermeable backing layer, a self-adhesive matrix based on polysiloxanes containing at least 1% by weight, preferably at least 2% by weight, more preferably at least 3% by weight, most preferably at least 5% by weight, of the therapeutic compound, and a protective film to be removed before use, in which
a. the matrix contains liquid microreservoir droplets comprising an amphiphilic solvent, in which the therapeutic compound is dissolved, and b. the concentration of the therapeutic compound in the microreservoir droplets is between 20 and 90% by weight of the saturation concentration
wherein the therapeutic compound is capsaicin or a capsaicin analog or a mixture thereof. |