发明名称 Rhinotopic therapy for the treatment of chronic rhinosinusitis biofilm disruption, treatment of mucosal granulation and sinus polyps
摘要 The herein disclosed invention is directed to methods of treating difficult to treat refractory or recalcitrant rhinosinusitis involving the steps of (1) topical application of antimicrobials/antibiotics and corticosteroids, (2) endoscopic debridement and cleansing to remove debris and biofilm, (3) endoscopic instillation of antimicrobials/antibiotics plus corticosteroids to the sinuses, and (4) hydrotherapy to disrupt/inhibit bacterial/fungal biofilm attachment to the sinus mucosa. Also disclosed is a kit of components for carrying out the treatment of this invention.
申请公布号 US2014336463(A1) 申请公布日期 2014.11.13
申请号 US201012657557 申请日期 2010.01.22
申请人 Shikani Alan H. 发明人 Shikani Alan H.
分类号 A61M11/00;A61M3/02;A61M31/00 主分类号 A61M11/00
代理机构 代理人
主权项 1. In the treatment of the disease of rhinosinusitis, wherein the sinus lining is inflamed due to bacterial, viral and/or microbial infection causing structural issues such as sinus ostium blockage; wherein the conventional medical therapy consists of antibiotics and/or topical nasal corticosteroids, which is not effective in an appreciable segment of the patients and may have to be repeated; and wherein, if the patient does not respond to the aforesaid medical therapy, sinus surgery may be recommended and, if performed, is not always effective and may have to be repeated; a multi-faceted rhinotopic therapy comprising the steps of nebulizing small-particle antimicrobials/antibiotics and/or corticosteroids for the treatment of the infection and/or inflammation, respectively; cleaning the sinus cavities from debris and/or biofilms sticking to the sinus mucosa, applying antimicrobials and/or corticosteroids directly inside the sinus cavities and/or the areas around the sinuses; and including the step of regular hydrotherapy, thereby avoiding repeated medical therapy and/or sinus surgery, and thereby providing a highly effective treatment modality for rhinosinusitis without significant side effects.
地址 Ruxton MD US