FORMULATIONS OF VITAMIN K ANALOGS FOR TOPICAL USE

摘要

The present invention provides topical formulations containing a vitamin K analog, e.g., menadione, that deliver a uniform, therapeutically effective concentration of the vitamin K analog to the skin in a vehicle which is stable, non-irritating, non-drying and cosmetically acceptable. These topical formulations are useful for the treatment and prevention of dermatological conditions associated with inflammation, particularly, dermatological conditions resulting from anti-EGFR therapies.

主权项

1. A method of treating a dermatological condition comprising topically administering to a patient a pharmaceutical formulation comprising a vitamin K analog, a lipophylic component, a gelling agent, and water.