发明名称 |
COMPOSITIONS FOR CELL CULTURE AND METHODS OF USING THE SAME |
摘要 |
Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product with potential improvements in antibody structure and function. |
申请公布号 |
WO2014182658(A1) |
申请公布日期 |
2014.11.13 |
申请号 |
WO2014US36908 |
申请日期 |
2014.05.06 |
申请人 |
ABBVIE INC. |
发明人 |
WANG, MIN;HOSSLER, PATRICK, M.;MCDERMOTT, SEAN, W.;RACICOT, CHRISTOPHER;CHEMFE, KOFI;FANN, JOHN |
分类号 |
A01N1/02 |
主分类号 |
A01N1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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