| 摘要 |
<p>The present invention relates to a method for preparing non-peptidic polymer and albumin assembly nanoparticles containing a poorly water soluble drug therein and capable of mediating in vivo delivery through solubilization and stabilization in an aqueous solution. Particularly, a non-peptidic polymer and albumin assembly and a poorly water soluble drug can be simultaneously dissolved even if using only an organic solvent, and thus the two components are mixed well even if a separate chemical or physical action is not applied. In addition, a method for preparing polyethylene glycol and albumin assembly nanoparticles according to the present invention does not contain a surfactant and a solubilizing agent, and thus does not cause a hypersensitive reaction or a toxic reaction due to the formulation of a poorly water soluble drug and can increase the compliance of a patient. Further, the present invention can also be useful for the stabilization and the like of inorganic nanoparticles for image/diagnosis and of various poorly water soluble drugs.</p> |
