发明名称 |
REDUCTION OF MICROGLIA-MEDIATED NEUROTOXICITY BY KV1.3 INHIBITION |
摘要 |
<p>Methods for deterring microglia-mediated neurotoxicity in a human or non-human animal subjects comprising the step of inhibiting or blocking the intermediate-conductance calcium-activated potassium channel Kv1.3 in microglia, such as in subjects how suffer from neurodegenerative diseases (e.g., Alzheimer's Disease) or ischemic/anoxic/hypoxic conditions. The inhibition or blocking of the KCa1.3 channels may be accomplished by administering a substance that inhibits Kv1.3 in microglia. Examples of Kv1.3 inhibiting substances include certain 5-phenoxyalkoxypsoralens, such as (4-Phenoxybutoxy)psoralen (PAP-1) as well as certain 4-phenoxybutoxy-substituted heterocyclic compounds.</p> |
申请公布号 |
EP2717871(A4) |
申请公布日期 |
2014.11.12 |
申请号 |
EP20120797546 |
申请日期 |
2012.06.08 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
WULFF, HEIKE;JIN, LEE-WAY;MAEZAWA, IZUMI |
分类号 |
A61K31/343;A61K31/085;A61K31/35;A61K31/353;A61K31/37;A61K31/47;A61K31/4709;A61K31/472;A61K31/517;A61P25/00;A61P25/28 |
主分类号 |
A61K31/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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