发明名称 |
ANALYSIS AND TARGETING OF ROR2 IN CANCER |
摘要 |
<p>ROR2 is provided as a therapeutic target and prognostic marker for cancers, which include without limitation specific carcinomas and sarcomas. This invention also provides for the use of conjugates comprising an antibody that recognizes and binds ROR2, and a cytotoxic agent. In the cytotoxic conjugates, the cell binding agent has a high affinity for ROR2 and the cytotoxic agent has a high degree of cytotoxicity for cells expressing ROR2, such that the cytotoxic conjugates of the present invention form effective killing agents. In a preferred embodiment, the cell binding agent is an anti-ROR2 antibody or an epitope-binding fragment thereof, more preferably a humanized anti-ROR2 antibody or an epitope-binding fragment thereof, wherein a cytotoxic agent is covalently attached, directly or via a cleavable or non-cleavable linker, to the antibody or epitope-binding fragment thereof.</p> |
申请公布号 |
EP2800975(A1) |
申请公布日期 |
2014.11.12 |
申请号 |
EP20130733927 |
申请日期 |
2013.01.03 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
NUSSE, ROELAND;VAN DE RIJN, JAN, MATTHIJS;EDRIS, BADREDDIN |
分类号 |
G01N33/574;A61K39/00;C07K16/28;C07K16/30;C07K16/40;C12Q1/68 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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