| 主权项 |
1. A process for preparing compounds of formula (I):in which
R1 represents 1-azabicyclo[2.2.2]oct-3-yl, R2 represents hydrogen or C1-C6-alkyl, R3 represents hydrogen, halogen or C1-C6-alkyl, A represents oxygen or sulfur, and the ring B represents benzo, pyrimido, pyrimidazo or pyridazino which is substituted by a radicals selected from the group consisting of halogen, C1-C6-alkanoyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6-acylamino, C1-C6-alkyl, C1-C6-alkyoxy, C1-C6-alkylthio, C1-C6-alkylamino, heteroarylcarbonylamino, arylcarbonylamino, C1-C6-alkylsulfonyl-amino, di(C1-C4-alkylsulfonyl)amino, arylsulfonylamino, di(arylsulfonyl)amino, C3-C6-cycloalkylcarbonylmethyl, 1,3-dioxa-propane-1,3-diyl, amino(hydroxyimino)methyl and benzo, or a salt, a hydrate or a hydrate of a salt thereof,characterized in that compounds of the formula
R1R2NH (II),in which R1 and R2 are as defined for formula I are reacted with a compound of the formula in which
R3, A and the ring B are as defined for formula I andX represents hydroxyl or a suitable leaving group,in an inert solvent, if appropriate in the presence of a condensing agent and if appropriate in the presence of a base. |
