Agent for reducing risk in onset of disease ascribable to non-dipper circadian rhythm of blood pressure

摘要

An agent for reducing risk in onset of diseases ascribable to non-dipping circadian profile of blood pressure is provided. This agent is capable of effectively lowering SBP from night to early morning in individuals with non-dipping circadian profile of blood pressure, in particular, normal individuals with normal SBP and DBP among them, and is thus capable of reducing risk in onset, particularly likely in the morning, of diseases caused by circadian variation of blood pressure. The agent is intended for administration to such subjects, and contains a hydrolysate or a concentrate thereof, containing Val-Pro-Pro and Ile-Pro-Pro and obtained by hydrolysis of animal milk protein.

主权项

1. A method for increasing magnitude of nocturnal or early morning decline in mean systolic blood pressure of a non-dipper individual, comprising orally administering a animal milk protein hydrolysate containing Ile-Pro-Pro tripeptide and Val-Pro-Pro tripeptide, or a concentrate thereof, to the non-dipper individual,
wherein said non-dipper individual has mean systolic blood pressure (SBP) of less than 130 mmHg and mean diastolic blood pressure (DBP) of less than 80 mmHg, and shows a less than 10% decline in mean systolic blood pressure during a time period of 0:00-5:00 compared to mean systolic blood pressure during a time period of 8:00-21:00, all as measured brachially every 30 minutes with a 24-hour ambulatory blood pressure monitor.