3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof

摘要

Disclosed is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof:;wherein R1 is
1: a C3-8 cycloalkyl C1-4 alkyl group,2: a C7-14 aralkyl group, in which the aryl moiety thereof is optionally substituted with the same or different 1 to 3 groups selected from the group consisting of:
(a) halogen,(b) C1-4 alkyl, which is optionally substituted with 1 to 3 fluorine atoms,(c) C1-4 alkoxy, which is optionally substituted with 1 to 3 fluorine atoms, and(d) C1-4 alkylcarbonyl, which is optionally substituted with C1-4 alkoxy,3: a five-to ten-membered heteroaryl-C1-4 alkyl group, in which the heteroaryl moiety thereof is optionally substituted with the same or different 1 to 3 groups selected from the group consisting of:
(a) halogen, and(b) C1-4 alkyl, or4: a C6-10 aryl C2-6 alkenyl group; andR2 is a cyano group or a nitro group.

主权项

1. A compound represented by Formula (II) or a pharmaceutically acceptable salt thereof: wherein A is one member selected from the group consisting of groups represented by Formulae (a) to (d) below: wherein R12a, R12b, and R12c are the same or different, and independently represent:
1: a hydrogen atom,2: a halogen atom,3: a C1-4 alkyl group, which is optionally substituted with 1 to 3 fluorine atoms,4: a C1-4 alkoxy group, which is optionally substituted with 1 to 3 fluorine atoms, or5: a C1-4 alkylcarbonyl group, which is optionally substituted with C1-4 alkoxy; R12d, R12e, and R12f are the same or different, and independently represent:
1: a hydrogen atom,2: a halogen atom, or3: C1-4 alkyl; and R22 is a cyano group or a nitro group.