Hexenone compounds and medical use thereof

摘要

The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.;

主权项

1. A compound of Formula I, or pharmaceutically acceptable salt or solvate thereof, wherein: A represents ═S, —SR4 or ═O; X represents F, Cl, Br or I; R1 represents phenyl; R2, and R3 are attached together to form morpholine; and R4 represents C1-C6 alkyl.