COMBINATION OF CLOPIDOGREL AND ASPIRIN

摘要

The present invention relates to a complex agent containing clopidogrel and aspirin, and more specifically, to a complex agent including a capsule containing granules obtained by coating a clopidogrel layer with a rapid release-preventing layer and aspirin granules obtained by coating an aspirin layer with an enteric layer. The present invention can fundamentally block a eutectic phenomenon by blocking the physical contact between the clopidogrel and the aspirin, and thus can prevent changes in the amount, elution properties, and bioequivalence of the agent in the short term and ensure the stability of the agent in the long term. Furthermore, the present invention can prevent the damage to the stomach wall by coating the aspirin with the enteric layer. In addition, the present invention can minimize the production of clopidogrel related substances without the change in the clopidogrel elution amount by containing a moisture-proof coating substrate in order to improve the stability of clopidogrel and its salts sensitive to moisture.